We consider |\Delta F| = 1 (F = S,C or B)
nonleptonic effective hamiltonian in a renormalization scheme which
allows to consistently use fully anticommuting \gamma_5 at any
number of loops, but at the leading order in the Fermi coupling G_F.
We calculate two-loop anomalous dimensions and one-loop matching
conditions for the effective operators in this scheme. Finally, we
transform our results to one of the previously used renormalization
schemes, and find agreement with the original calculations.